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I suspect that since the borg needed such detailed info on picards body and they altered starfleet transporters that it only would work on “known” species in the federation databases.
Ultimately the assimilated just needed to out number and overwhelm the older old un effected backed up by complete computer ship control of all federation vessels. The plan never needed total assimilation.
SO my answer is that they would probably be immune.
Sometimes the controls are just better on the Emulators at least on older PC ports as they would do dumb stuff like require a mouse / keyboard for menus etc.
On the steam deck in particular when getting steam versions of games with lower steam deck compatibility ratings it often comes down to odd menu issues or controller support.